A novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (FHV-1)
نویسندگان
چکیده
منابع مشابه
In vitro comparison of antiviral drugs against feline herpesvirus 1
BACKGROUND Feline herpesvirus 1 (FHV-1) is a common cause of respiratory and ocular disease in cats. Especially in young kittens that have not yet reached the age of vaccination, but already lost maternal immunity, severe disease may occur. Therefore, there is a need for an effective antiviral treatment. In the present study, the efficacy of six antiviral drugs, i.e. acyclovir, ganciclovir, cid...
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Infection with feline herpesvirus-1 (FHV-1) is a major cause of upper respiratory and ocular diseases in Felidae. We report the first complete genomic sequence of FHV-1, as well as the construction and characterization of a bacterial artificial chromosome (BAC) clone of FHV-1, which contains the entire FHV-1 genome and has the BAC vector inserted at the left end of U(L). Complete genomic sequen...
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The genome of feline herpesvirus type 1 (FHV-1), the major cause of viral upper respiratory disease in cats, contains several genes encoding homologues of herpes simplex virus type 1 (HSV-1) glycoproteins. Restriction mapping studies have indicated that the group D genome of FHV-1 contains a unique short region that is 9.0 kb long. The nucleotide sequence of a 6.2 kb portion of this region was ...
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Upper respiratory tract diseases (URTD) are common clinical problem in cats worldwide. Feline calicivirus (FCV) and feline herpesvirus type 1 (FHV-1) are the main primary pathogens. Feline immunodeficiency virus (FIV) and Feline leukemia virus (FeLV) are also among the most common infectious diseases of cats which suppress the immunity. Oropharyngeal and conjunctival swabs and blood samples wer...
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FELINE HERPESVIRUS Despite the ready availability of vaccines and antiviral drugs effective against feline herpesvirus type 1 (FHV-1), this virus remains a major, common, and frustrating pathogen of cats worldwide. FHV-1 has been associated with acute, chronic, and recurrent conjunctivitis, ulcerative and stromal keratitis, corneal sequestrum, eosinophilic keratitis, anterior uveitis, dermatiti...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2016
ISSN: 0022-1317,1465-2099
DOI: 10.1099/jgv.0.000451